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Kerala PSC exam syllabus for Analyst Grade 3 (Drugs Control Department)


Here you can read about the detailed syllabus of examination for the post of Analyst Grade -3 in Drugs Control Department. The exam is conducted by Kerala PSC on December 2011. The below syllabus was announced by the Kerala Public Service Commission.

Post: - Analyst Grade 3
Department - Drugs control
Category Number: - 180/2010
Number of Vacancies : - 2

As per the notification published by Kerala PSC on 30th June 2010, for the post of Analyst Grade 3 in Drugs Control Department; an exam will be there for the candidates on December 2011.

Candidates should have the given qualification that is Degree in Pharmacy from a recognized University. The list of selected candidates published by the Commission had remained in force for over one year and now the PSC will conduct the exam for the same to select the desired candidates for the post.

Syllabus


Main Topics are: -
1. Pharmaceutical Chemistry
2. Pharmaceutical Analysis
3. Pharmaceutics
4. Pharmacology
5. Pharmacognosy
6. Pharmacy Practice
7. Pharmaceutical Jurisprudence
8. Microbiology


1. Pharmaceutical Chemistry


Sources of impurities in pharmaceutical substances. Gastrointestinal agents and related compounds, Topical agents, Dental products, Electrolytes used for replacement therapy, Gases, Essential and Traceions, pharmaceutical Aids, Sclerosing agents, Expectorants, Sedatives, Antidotes and Respiratory stimulants.

Study of classification, mechanism of action and uses of selected drugs – General anaesthetics, Local anaesthetics, sedatives and
Hypnotics, Antipsychotics, Anticonvulsants, Antidepressants, adrenergic antagonists, cholinergic drugs, cholinergic blocking agents, Antipyretics, Narcotic analgesics, Non steroidal anti inflammatory agents, Antihistaminic agents, H2 receptor antagonist and protein pump
inhibitors, Diuretics, Antihypertensive agents, Oral hypoglycemic agents and anti-thyroid agents, Local anti infective agents, Anti fungal agents, Anti-tubercular agents,Anti-protozoal agents, Anthelmintics, Antimalarials, Sulfonamides and Sulfones, Antibiotics, Antiviral agents and Anti-neoplastic agents.

2. Pharmaceutical Analysis


Different techniques of analysis. Neutralization titrations, Non aqueous titrations, precipitation titrations, Complexometric titrations,
Oxidation – reduction titrations,Gravimetric analysis, Diazotisationstitrations, Kjeldhal method of nitrogen estimation, Gasometry, Karl Fischer method. Chromatography, Ion Exchangers, Potentiometric titrations, Conductometric titrations, Thermal Analysis, Polarography, Amperometry, Electrophoresis, Turbidimetry and Nephelometry, UV and visible Spectrophotometry, Fluorimetry, Nuclear Magnetic Resonance Spectroscopy, Mass Spectrometry, Flame Photometre, EmissionSpectroscopy, Atomic Absorption Spectroscopy, X-Ray diffraction
& Radio Immuno Assay, Quality Assurance.

3. Pharmaceutics


Pharmaceutical Calculations, Posology. Powders, Solutions, Aromatic Waters, Mixtures, Emulsions, Lotions, Liniments, Paints, Lozenges, Jellies, Pastes, Suppositories, Extraction. Physical, Chemical, Therapeutic incompatibilities. Heat Transfer, Mechanical separation, Filtration and Centrifugation, Size Reduction and Size separation, Evaporation, Distillation, Dying and Mixing.

Diffusion and Dissolution, Liquid interfaces, surface active agents, Disperse System, Colloids, Viscosity and Rheology, Kinetic and Drug
Stability, Micro meritics and Power Rheology, Complexations methods for enhancement of stability, Radio Pharmaceuticals.
Bio-Pharmaceutics, Absorption, Distribution, Metabolism and Elimination. Compartment models. Pharmaceutical Tablets, Capsules,
Sterile products, Pharmaceutical Aerosols, Surgical ligatures and Sutures, Blood products and Plasma substitutes, Stability problems and
stabilization techniques of Pharmaceutical dosage forms. Cosmetics, Controlled drug delivery systems, Microencapsulation and transdermal
drug delivery systems.

4. Pharmacology


Definitions of Drugs, proprietary name, non-proprietary name, Pharmaco-therapeutics, Pharmaco-kinetics, Pharmaco-dynamics, toxicology, Bioequivalence, Chemotherapy, drug interaction, adverse drug reactions & Pharmaco-vigilance, Pharmaco-economics, Pharmacoepidemiology, orphan drugs.
Routes of drug administration and factors governing choice of routes ,Pharmaco-kinetics – Absorption, distribution, Bio-transformation,
Excretion, Pharmaco-dynamics – Drug Dose & Dosage, Rational use of Medications

Pharmaco-genetic variation in drug action, Principles of Toxicology
Drug interactions – Adverse effect of Drugs, Pharmacology of Drugs in special groups – pregnancy, lactation peadiatrics and the elderly Chrono
Pharmacology
Pharmacology of the following classes of Drugs
Drugs acting on autonomic nervous system, Autocoids and their antagonists, Cardio Vascular drugs, Drugs acting on respiratory tract,
Drugs acting on endocrine system, Bio assay of insulin, digitalis, adrenaline, acetyl-choline, histamine, Oxytocin, d-tubocurarine, Antihaemophilic fraction, Heparin Sodium, Diphtheria antitoxin, Anti rabies vaccine. Drug discovery and new drug development

Bio-informatics
Pharmacology of the following groups of drugs – Drugs acting on central nervous system, Local anaesthetics, Drugs acting on uterus,
Drugs affecting renal function: Diuretics & antidiuretics, Drugs acting on the blood & blood forming organs, Pharmacology of vitamins , Heavy metals & Heavy metal antagonists, Enzyme in therapy, Therapeutic gases, Drugs acting on skin.
Anti-microbial Drugs & Chemotherapy, Immuno-Pharmacology, Gene therapy.

5. Pharmacognosy


Study of the following families with special reference to medicinally important plants, Apocynaceae, Solanaceae, Umbelliferae, Leguminosae,
Rubiaceae and Labiatae.
Systematic Phamacognostic study of following – Carbohydrates and derived products –Lipids
Study of drugs containing resins and resin combinations
Study of tanninsand tannin containing drugs Volatile Oils , study of fibres used in Pharmacy. Study of
pharmaceutical aids. Drugs of animal origin.
Chemistry, biogenesis and pharmacological activity of medicinally important monoterpenes, sesquiterpenes, Diterpenes and Triterpenoids
Glycosides : Chemistry and biosynthesis
Alkaloids: Chemistry, Biogenesis and Pharmacological activity
Chemistry and Biognesis of medicinally important ligans, Quassinoids and Flavonoids
Plant tissue culture, Totipotency, types of cultures, nutritional requirements, growth and their maintenance, Application of plant tissue culture in pharmacognosy.
Gene Transfer, Gene mapping of plants, transgenic plants, introduction to DNA finger printing
Herbal Drug Technology – Development and Evaluation of herbal formulations.

Adulteration and Evaluation of crude drug. Standards for herbal formulation. Herbaceous health foods. Herbal cosmetics. Study of biological sources, cultivation, commercial varieties, chemical constituents, substitutes, adulterants, uses, diagnostics, macroscopic and
microscopic features and specific chemical tests of the following groups of drugs containing – glycosides: Saponins: Cardio active sterols :
Anthroquinone cathartics:
Studies of traditional drugs, common vernacular names, botanical sources, morphology, chemical nature of chief constituents,
pharmacology, categories and common uses and marketed formulations of indigenous drugs – Amla, Kantakari, Satavari, Tylophora, Bhilwa, Arjuna, Kalijiri, Rasna, Unarnava, Chirata, Apmarg, Gokhru, Shankapushpi, Brahmi, Methi, Lahsun, Palash, Guggal, Gymnema, Shilajit and Neem.
Introduction to ayurvedic preparations like Asavas, Gutikas, Tailas, Choornas, lehyas and Bhasmas.
Systematic study of source, cultivation, collection, processing, chemical constituents, adulterants, uses, diagnostics, macroscopic and microscopic features and specific chemical tests of the following alkaloids containing drugs: Pyridine & Piperidine, Tropane, Quinoline & Isoquinoline, Indole, Imidazole, steroidal, Alkaloidal amines, Glycoalkaloid, Purines.

Introduction, classification and study of different chromatographic methods and their application in evaluation of herbal drugs.
Preparation of the extracts and various extraction techniques including super critical fluid extraction. Chemotaxonomy of medicinal plants. Marine Pharmacognosy, novel medicinal agents from marine sources. Classification and preparation of allergenic extracts.
Biological sources, preparation, identification tests and uses of following enzymes: Diastase, Bromalein, Papain, Maltase. Protein containing drugs: Gelatin Collagen, Spirulina

Pharmacy Practice
Basic Principle of Cell injury & Adaptation. Inflammation & Repair.
Etiology, Pathophysiology & Clinical Significance of Common diseases.
Neoplasms: brief account on the etiology & pathogenesis of Cancer.
Concept of Health & Disease. Nutrition: Classification of food
requirements, Balanced diet, Nutritional Deficiency Disorders, their treatment and prevention.
Environment & Health: Sources of Water Supply, specifications for drinking water, purification of water, water pollution, health & air, noise,
light
National Immunization schedule, principles of disease control & prevention, hospital acquired infection, prevention & control.
Demography & Family Planning
Communicable Diseases: Causative agents, Modes of Transmission, Symptoms and prevention, chicken Pox, Measles, Influenza, Diphtheria,
Whooping Cough, Tuberculosis, Poliomyelitis, Hepatitis, Cholera, Typhoid,
Food Poisoning, Helminthiasis, Malaria, Filariasis, Rabies, Trachoma, Tetanus, Leprosy, Syphilis, Gonorrhea & AIDS
Non-Communicable Diseases:- Etiology, preventive measures & control
– Cancer, Diabetes Mellitus, Blindness, Cardio-vascular diseases.
First Aid : Emergency treatment of shock, Snake bite, Burns & Heart diseases.

Hospital Pharmacy : Definition, Classification, Objectives, Functions,
Organisation of Hospital Pharmacy.
Pharmacy & Therapeutic Committee : Hospital Formulary. Drug Store Management & Inventory control. Drug Distribution System in Hospitals.
Central Sterile Supply Unit & their management. Professional activities of Clinical Pharmacist. Interpretation of clinical
Laboratory tests and its significance. Drugs & Poison Information Service. Clinical Pharmacokinetics & individualization of drug therapy. Adverse drug reactions. Definition & implication of evidence based medicine.
Pharmacoepidemology.
Clinical Management of the following organ disorders – Cardio-vascular disorders, Central Nervous Disorders, Respiratory disorders, Gastro intestinal disorders, Endocrine disorders, Infectious disorders, Hemopoietic disorders.

7. Pharmaceutical Jurisprudence


Pharmacy Act 1948, Drugs & Cosmetics Act 1940, Medicinal Toilet Preparations (Excise Duties) Act and Rules, Narcotic Drugs & Psychotropic
Substances Act, Drugs & Magic Remedies (Objectionable Advertisements) Act
Drug Prices Control Order, AICTE Act, Patents Act, Trade & Merchandise Marks Act, States Shops & Establishments Act, Minimum
Wages Act, Factories Act, Prevention of Food Adulteration Act & Rules, Prevention of, Cruelty to Animals Act, Medical Termination of Pregnancy Act, The Poisons Act.

8. Microbiology


Classification of microbes and bacterial taxonomy. Structure of bacterial cell. Identification methods of microbes, stains and types of
staining techniques. Bacterial nutrition, cultivation of bacteria, culture media, its classification, Aerobic and Anaerobic culture methods. Isolation of pure culture. Classification and structure of viruses. Cultivation of viruses, Viral replication. Bacteriophages, Phage typing. Introduction to fungi of medical and pharmaceutical importance. Fungal reproduction and cultivation. Microbial genetic and variation. Gene cloning and their applications. Immunity. Immunological preparations. Active & Passive immunization, Vaccines and Sera, Their preparations, standardization & storage. Antigen – Antibody reactions & their applications. Control of Microbes by Physical & Chemical methods. Antibiotics, Microbial assay of Antibiotics, Fermentation process, Enzyme Immobilization, Microbial Transformation.


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